Railway Budget: List of trains

Railway Minister Mamata Banerjee announced that 54 new trains will be introduced.

Here is a list of the trains with their origin and destination points:

Tanakpur - Jauljobi
Bilaspur - Leh
Amethi - Shahganj via Sultanpur
Bahadurgarh - Jhajhar
Ajmer - Kota
Vyas - Kapurthala
Guwahati - Mumbai Karambhumi train
New Jalpaiguri - Amritsar Karambhumi train
Janambhumi trains will run once a week
Ahmedabad - Udhampur Janambhumi train
16 Bharat Tirth train between Himachal - Kanyakumari
Indore - Mumbai New Duranto
Sultanpur - Mumbai
Sultanpur - Ajmer
Kolkotta - Ajmer
Hardwar - Mumbai
Sambhalpur - Hawarh
Gwalior - Pune
Ahmedabad - Jodhpur
Kolkotta - Darbhanga
Gwalior - Chindwara
Hawarh - Shirdi
Trains will be named after great leaders
First rail line in Andaman and Nicobar Islands to connect Port Blair to Diglipur, farthest town of North Andaman

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How arsenic exposure triggers tumour growth

Washington, Feb 24 (ANI): Scientists have discovered the mechanism by which the environmental toxin arsenic leads to adverse health effects, including bladder cancer.

"In a collaborative investigation we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated diseases, such as bladder cancer," said Margaret R. Karagas, professor in the Department of Community and Family Medicine at Dartmouth Medical School.


"We provide important insight into the etiology of arsenic-induced disease, potentially relevant to the millions of people worldwide who are exposed to arsenic," she added.

While the correlation between exposure to arsenic resulting in human tumours such as those derived from bladder, lung and skin is well established, the molecular mechanisms driving this connection is unclear.

Karagas and colleagues examined the hypothesis that the secreted protein called Hedgehog, a key oncogenic signaling pathway, might be activated by arsenic. Activation might underlie the mechanism by which arsenic acts as a co-carcinogen.

Using experimental data from cell cultures and results of epidemiologic studies, the researchers found that arsenic activates the Hedgehog signaling by decreasing the stability of the repressor form of GLI3, which is one of the transcription factors that regulate Hedgehog activity.

Also, Karagas and colleagues found high levels of arsenic exposure associated with high levels of Hedgehog activity.

These study results are published in Cancer Research, a journal of the American Association for Cancer Research. (ANI)

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